Syntheses of functionalized indium porphyrins for monoclonal antibody labeling.
Identifieur interne : 007D22 ( Main/Exploration ); précédent : 007D21; suivant : 007D23Syntheses of functionalized indium porphyrins for monoclonal antibody labeling.
Auteurs : RBID : pubmed:8950480English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Porphyrins.
- chemical : Antibodies, Monoclonal, Indium Radioisotopes, Serum Albumin.
- Animals, Cattle, Magnetic Resonance Spectroscopy.
Abstract
The syntheses and characterizations of five differently hydrosoluble monosubstituted aryl porphyrins are reported. Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reaction for the definition of the best experimental coupling conditions; the transposition to the labeling of anti-CEA monoclonal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity.
DOI: 10.1021/bc960045i
PubMed: 8950480
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Their metallation with indium-111 was achieved and provided tracers with strong specific activities. The covalent coupling between indium-111 porphyrins and BSA served as a model reaction for the definition of the best experimental coupling conditions; the transposition to the labeling of anti-CEA monoclonal antibody was realized. The conjugates exhibited an in vitro good mAb-labeling efficiency, as well as a good preservation of immunoreactivity.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8950480</PMID><DateCreated><Year>1997</Year><Month>03</Month><Day>14</Day></DateCreated><DateCompleted><Year>1997</Year><Month>03</Month><Day>14</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">1043-1802</ISSN><JournalIssue CitedMedium="Print"><Volume>7</Volume><Issue>6</Issue><PubDate><MedlineDate>1996 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Bioconjugate chemistry</Title><ISOAbbreviation>Bioconjug. 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